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Mak Lab
The Hong Kong University of Science and Technology
Our Research
Our laboratory uses the nematode C. elegans as a discovery tool to elucidate the genetic pathways and molecular mechanisms that regulate food intake, fat storage and mobilization.
We seek to address the following questions:
1
What are the regulatory mechanisms that govern lipid droplet size?
2
How do lipid droplets physically and functionally couple with the endoplasmic reticulum?
3
How do lipid droplets communicate with
the peroxisomes?
Most of our studies begin with large-scale forward genetic screens in C. elegans. We then employ genetics, lipid and protein biochemistry, proteomics, high-throughput sequencing, fluorescence and electron microscopy to address our questions at a molecular level in C. elegans and mammalian models.
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